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An indirect treatment comparison of the efficacy of semaglutide 1.0 mg versus dulaglutide 3.0 and 4.5 mg

315 The expression levels of GLP-1R, PKA/CREB signaling pathway components, and inflammation-related proteins (such as TNF-, IL-1, and IL-6) in the rat knee cartilage tissue were measured using Western blot and immunoprecipitation techniques

GLP-1 RAs exhibit anti-inflammatory properties through inhibition of NF-B pathways and macrophage infiltration in adipose tissue

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The glucagon receptor component in retatrutide creates a unique metabolic profile that the other two lack