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Atherosclerosis Statin therapy produces an estimated: 60% in the number of cardiac events 17% in stroke Greater benefit with high-intensity statins Familial hypercholesterolemia Familial hypercholesterolemia Lipid Disorders (FH) Genetic disorder that causes a loss of function Loss of Function Inflammation of the LDL receptor Receptor Receptors are proteins located either on the surface of or within a cell that can bind to signaling molecules known as ligands (e.g., hormones) and cause some type of response within the cell

Furthermore, as anticipated, the response of primary human hepatocytes, i.e

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J Appl Physiol 63:152157 Huang J, Philbert MA (1995) Distribution of glutathione and glutathione-related enzyme systems in mitochondria and cytosol of cultured cerebellar astrocytes and granule cells

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