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The first 4 to 8 weeks are usually a dose-escalation phase at lower, "starter" doses designed to allow the body to adjust to side effects like nausea

Briefly, 10 l of serum was incubated with the top 12 abundant serum protein depletion kit (Thermo Scientific Pierce, Cat# 85164) and digested with trypsin on S-Trap column (ProtiFi, NY)

10.1002/hep.29661 Hepatology 81 LiottaL