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aIn a phase 1 clinical study conducted with PF-06882961, the half-life and the area under the plasma drug concentration-time curve did not differ between the fed and fasted states

They get off the diet, then they get much better results and they think, oh man, it's something mysterious here and this mystery resolved

That's a follow-up problem

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Some people may develop antibodies to exenatide, the active ingredient in Byetta, which may make the drug less effective in improving blood sugar levels