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Retatrutide titration: 1mg to 12mg The retatrutide titration protocol tested in Phase 3 trials follows a five-step escalation: Weeks 1-4: 1mg weekly Weeks 5-8: 2mg weekly Weeks 9-12: 4mg weekly Weeks 13-16: 8mg weekly Week 17 onward: 12mg weekly (maximum dose) The dose doubles at each step (with the exception of the 1mg to 2mg increase), which is a faster escalation rate than either semaglutide or tirzepatide

DEXA scans or quality body composition scales track fat versus lean tissue changes

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This transitional phase culminates in relief as your body reaches its new equilibrium

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10.1089/ars.2013.5236 [DOI] [PMC free article] [PubMed] [Google Scholar] Wang Q., Zhan S., Liu Y., Han F., Shi L., Han C., et al