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The results of a study concerning the graded expression of the Keap1 gene in mice demonstrated that a 50% reduction of Keap1 activity does not induce Nrf2 accumulation, whereas a 75% reduction is enough to elicit this effect (Taguchi et al., 2010)
Kimura, S., Dedon, P
In several studies, the anti-inflammatory effect improved inflammatory parameters and histopathological features in irradiated mice (2,10,139)
Zaros C, Genin E, Hellman U, Saporta MA, Languille L, Wadington-Cruz M, Suhr O, Misrahi M, Plante-Bordeneuve V
10.1021/acs.chemrev.8b00460 72 MathaiJ
[DOI] [PMC free article] [PubMed] [Google Scholar] 91.Olsson E., Byberg L., Karlstrom B., Cederholm T., Melhus H., Sjogren P., Kilander L
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