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Blood Pressure Reduction: Users typically experience 4-8 mmHg systolic reductions, mediated by weight loss, salt sensitivity reduction, and improved endothelial function

Studies have shown that behavior change is difficult, and simply offering brief advice on diet and exercise is not enough to drive long-term success

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However, the FDA black-box warning about medullary thyroid carcinoma (MTC) and thyroid C-cell hyperplasia means semaglutide is contraindicated in patients with personal or family history of MTC or multiple endocrine neoplasia syndrome type 2

Notably, these drugs are currently not covered for weight loss in Medicare, due to a long-time exclusion of treatment for weight loss