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However, pro-inflammatory mediators in VF and brain are suppressed during later stages of AD, indicating that neuro-inflammation-mediated neurodegeneration occurs mainly in the early or a specific stage of AD rather than the whole clinical course (68)

Whether pharmacological TREK-1 blockade (which is partial and reversible, unlike genetic knockout) carries seizure risk at therapeutic doses is unknown

Within Harbour Biomed itself, they and Kelun Biotech licensed out assets to a newco in Jan 2025 called Windward bio to develop a TSLP antibody HBM9378/SKB378, providing a $45 mn upfront, with $970 mn in potential milestones

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