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Its primary actions include: Inhibiting the reuptake of dopamine and noradrenaline in the central nervous system Minimal effect on serotonin pathways, distinguishing it from most other antidepressants Potential appetite suppression as a secondary effect, though this is not its primary indication Reducing nicotine cravings through dopaminergic pathways Bupropion is metabolised primarily in the liver by the CYP2B6 enzyme system, producing active metabolites

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However, this increased production can sometimes result in uneven skin tone, dark patches, or hyperpigmentation

[Crossref] Azzam AY, Essibayi MA, Farkas N, et al

Retatrutide and orforglipron are furthest along in testing, while survodutide may take longer

Vomiting episodes lasted a median of 2 days