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Recent surveillance data suggests that the frequency of NAION reports is similar for semaglutide and tirzepatide, with preliminary incidence rates of approximately 8.9 per 100,000 person-years for semaglutide and 9.7 per 100,000 person-years for tirzepatide

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however, a mixed-meal tolerance test (MMTT) revealed unsatisfactory postprandial insulin secretion (Table 1a)

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At room temperature, the rate increases measurably