Conclusions: Linagliptin resulted in a greater HbA1c reduction in the high GLP-1 prediabetes and T2D compared to low GLP-1 groups
These medications are vastly different, despite being in the same medication class, agrees Jodie Pepin, Pharm.D., clinical pharmacy program manager at Harbor Health in Round Rock, Texas
The Wegovy FDA label carries a clear precaution against use in pregnancy, and animal studies at exposures below the human clinical dose showed embryofetal toxicity including reduced fetal growth and skeletal malformations
6,8 Studies looking at higher doses, such as one comparing 12.5mg, 25mg, and 50mg, found a non-dose-dependent steady-state level maximum at the 25mg dose
More water means a lower concentration and larger, potentially more measurable volumes for small doses
Three weeks without scale movement after months of consistent loss often precedes a sudden drop