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Moreover, high glucose levels activate the NLRP3 inflammasome, promoting pyroptosis and disrupting estradiol synthesis (Xu R

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4.2 Promotion of insulin secretion GLP-1 stimulates insulin secretion in a glucose-dependent manner through specific receptors expressed on pancreatic cells.GLP-1R is a family of secretins (class B) that couples GLP-1 to downstream cell responses, and conformational changes in the receptor upon ligand binding facilitate the interaction between its intracellular region and signaling proteins (Jones et al., 2018)

Signs of overdose may include vomiting, diarrhea, loss of appetite, or increased thirst and urination

Each is an independently manufactured and tested reference compound, supplied as a lyophilised solid