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However, when lycopene was used in combination with hyaluronidase, the effect was comparative as that of lycopene alone (Johny et al., 2019)

We chose 2 cases in the high ACTL6A group and 2 cases in the low ACTL6A group for PDX experiment

Glutathione peroxidase 4 (GPX4) is a selenoenzyme that uses GSH as a co-factor to regulate lipid peroxidation of cell membranes during increased oxidative stress

The review highlights FOXO4-DRI's unique mechanism as a peptide-based senolytic with high selectivity for senescent cells, while noting challenges for clinical translation including peptide delivery and stability

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