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Biochem J 353:411416
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The content of melanin in melanocytes was increased by maclurin in a dose-dependent manner, by a mechanism involving the activation of the cAMP/PKA/CREB signaling pathway, which in turn increased tyrosinase, MITF and their downstream TRP-1 and Trp-2 protein content, while also involving the activation of p38 MAPK and p44/42 MAPK pathways
We previously stated that we plan to pursue CBE endorsement for the measure's implementation in the ASC setting in a future measure endorsement cycle and we would continue to monitor implementation of the measure as part of the standard measure maintenance process
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