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Cell culture and stimulation Normal human epidermal keratinocytes (NHEKs) were purchased from Takara Bio (Shiga, Japan) and cultured in Keratinocyte Basal Medium (KBM) overnight prior to human recombinant rIL-22 stimulation (200 ng ml 1 , R&D Systems, Minneapolis, MN)

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It features Carnipure LCarnitine, which helps transport fatty acids into cells for energy production and supports cardiac muscle recovery, and LTaurine, an amino acid essential for normal heart contractility and rhythm

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