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Phase 2b primary endpoints failed in the largest published trial

Dihexa (full name: N-hexanoic-Tyr-Ile-(6) aminohexanoic amide) is technically a peptidomimetica small molecule designed to mimic peptide binding activity while having improved stability and bioavailability compared to peptides

expect mild energy boosts

Its mechanism of action is context-dependent, primarily functioning through the induction of protective autophagy via the AMPK-mTOR pathway and the activation of the antioxidant AhR-Nrf2 axis

doi: 10.1210/jc.2007-1290 221 BaasEMRomijnMvan der PalSMVrijlandtEJLERotteveelJFinkenMJJet al

Isr Med Assoc J IMAJ 18(9):519524 Quintero OL, Amador-Patarroyo MJ, Montoya-Ortiz G, Rojas-Villarraga A, Anaya JM (2012) Autoimmune disease and gender: plausible mechanisms for the female predominance of autoimmunity