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Researchers have found it to be highly effective when used to reduce excess adnominal fat accumulation in adults with human immunodeficiency virus (HIV) who have developed lipodystrophy [1]

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Research using MC4R knockout mice and selective MC4R antagonists has established MC4R as the primary receptor mediating MT-IIs pro-erectile and pro-sexual effects with MC4R-null mice showing substantially reduced or absent MT-II-induced erections and sexual behaviour, and MC4R-selective antagonists blocking these responses at doses not affecting MT-IIs melanogenic activity