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Cholecalciferol is metabolized to its active form, calcitriol, which increases the body's absorption of calcium and phosphorus

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Approximately equal numbers of patients were randomized to receive placebo, 100 mg of sitagliptin once daily, 500 mg or 1000 mg of metformin HCl immediate-release twice daily, or 50 mg of sitagliptin twice daily in combination with 500 mg or 1000 mg of metformin HCl immediate-release twice daily

doi: 10.1038/s41467-018-06812-y 52 SmithALWhitehallJCBradshawCGayDRobertsonFBlainAPet al

This can result in hard, infrequent stools that are difficult to pass