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Lactic acidosis portends a poor prognosis (by Kings College Hospital (KCH) criteria), and the mechanism of lactic acidemia is two-fold: NAPQI being present in excess and causing mitochondrial dysregulation, followed in subsequent hours by tissue hypoxia and decreased hepatic metabolism and clearance of lactate, leading to a two-hit effect on worsening of the lactic acidosis condition
Research indicates that curcumin influences the metastasis of certain malignancies by targeting metastasis (Talmadge and Fidler, 2010
Even moderate alcohol intake can substantially reduce the caloric deficit necessary for weight loss, potentially explaining poor treatment response in otherwise adherent patients
Lilly wants metabolism to be a therapeutic base, not a narrow franchise
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