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The role of reactive oxygen species in the rheumatoid arthritis-associated synovial microenvironment

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39 In addition, the reactive aldehydes such as acrolein and 4-hydroxy-2-nonenal (4-HNE) formed from lipid peroxidation cause damage to the epithelial cells, acrolein is unstable and toxic, whereas 4-HNE in high concentrations is capable of inducing caspase (a major promoter of cell apoptosis)

NanoBiomed Res

76 Understanding these multifaceted roles is essential for developing effective cancer therapies