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If you receive a product and check its pH and it is below 4.5, the copper peptide is likely partially degraded or destabilized

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Rodent studies typically use 10 mcg/kg to 10 mg/kg via injection or orally

In certain embodiments, any controlled-release otic formulation described herein increases the exposure of an active agent and increases the Area Under the Curve (AUC) in otic fluids (e.g., endolymph and/or perilymph) by about 30%, about 40%, about 50%, about 60%, about 70%, about 80%, about 90%, about 100%, or higher than 100%, compared to an otic formulation that is not a controlled-release otic formulation

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