This is the first Phase 3 GLP-1-class readout that specifically demonstrates symptomatic benefit in knee osteoarthritis beyond what would be expected from weight loss alone, and it opens the possibility, still to be confirmed in dedicated trials, that GLP-1 receptor signaling has direct anti-inflammatory or disease-modifying effects on joint tissue
This is important because while a large number of immune cells in the gut are activated by GLP-1 very few immune cells containing GLP-1 receptors are present in other organs
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As Young remembers, 'We couldnt predict weight loss or weight gain with these drugs.' One of the challenges was that enhanced insulin secretion normally increases body weight
Back Brown, M, Goldstein, J, Podolsky, DK, et al (1 Sept 2020) 'In Memoriam: Dr