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2015), as well as in a mouse model of Alzheimers Disease (Han et al

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However, reaching optimal glycemic control typically requires 12-16 weeks, particularly as the dose is gradually titrated upward according to FDA-approved protocols

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However, in OA, M2 numbers are limited and may shift toward an M1-like phenotype under sustained inflammatory stimuli, reducing their capacity to maintain iron homeostasis (109, 110).Together, these insights support the hypothesis that iron metabolism in M1 macrophages not only contributes to ferroptosis susceptibility in OA, but also represents a potential immunometabolic checkpoint for therapeutic intervention