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The FDA has only approved Wellbutrin XL (24-hour extended-release) for the treatment of SAD

Changes in the microbiome in models of polycystic ovary syndrome (PCOS) have been linked to weight reduction, while studies on neurobehavioral effects have revealed lower inflammation in the hippocampus and increased neurogenesis, thereby supporting the involvement of GLP-1RAs in the GBA [48-51]

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Less common than SC (Novinscak et al., 2008)

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Peripherally, they improve insulin sensitivity, reduce hepatic lipotoxicity, and attenuate systemic and hepatic inflammation (Jones and Brierley, 2025