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Loss of MED1 significantly enhances keratinocyte proliferation and disrupts hair follicle cycling, while SRC3 deficiency impairs lipid metabolismassociated structures such as glucosylceramides and lamellar bodies, as well as 1,25(OH)D-induced ductin expressionphenotypes that partially mimic VDR deficiency [125,126,127,128]

The antioxidant response signals induce the activation of nuclear factor erythroid-derived 2-like-2 (Nrf2)

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