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This cell-specific expression of MCTs in the CNS facilitates the proposed glia-neuron lactate shuttle (Figure 2), which depends on lactate being produced and released from astrocytes and oligodendrocytes (via MCT1 or possibly MCT4) and taken up by neurons (via MCT2) during neuronal activities (Pierre et al., 2000

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Individuals with the CT genotype had lower hypertension risk, systolic blood pressure, blood glucose, and plasma MDA levels than those with the CC genotype, suggesting that the PPARD rs7770619 SNP could be a potential candidate gene for hypertension [248]

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26,27 Fat provides 90% calories, and its predominant source is food-derived LCT, and a 3:1 or lower ratio may be used

Benefits accrue over weeks to months rather than immediate effects