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GLP-1 (glucagon-like peptide-1) is a hormone your gut releases after meals

Therefore, it can be concluded that inhibiting glucagon secretion is critical in situations where blood glucose levels need to be controlled or lowered

Gerhard et al., 2016)

Regarding safety, gastrointestinal adverse events, such as nausea, vomiting, and diarrhea, are the most common, with a higher incidence observed with short-acting formulations

4.1 Exendin 4-based agents Exendin-4, a 39-amino acid peptide with 53% sequence homology to human GLP-1 [ Figure 2 ], was originally isolated from Heloderma suspectum lizard venom by using an amino acid sequencing assay targeting peptides with an amino-terminal histidine residue (His 1 ) (83)

It is well understood, extensively studied, and forms the backbone of modern GLP-1 therapy