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JAMA 2015;314:68799.ArticlePubMed 15

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The most common side effects are gastrointestinal and tend to improve after the first few weeks: Nausea, vomiting, or diarrhea (most common, especially early on) Constipation or stomach discomfort Reduced appetite Less common but serious side effects include pancreatitis, gallbladder issues, and low blood sugar particularly in patients taking diabetes medications

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In fact, most of the B12 you eat or drink eventually leaves your body in the form of urine

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