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One possibility that needs to borne in mind is that the majority of these protein thiol modifications may be a response to changes in the cellular milieu, rather than nodes of regulation 55

This reaction generates ATP without the need for the presence of oxygen and thus the expression of PKM2 is increased in many cancer cells

Cell Commun Sign 11:118

Available from: [15] Hundt M, Basit H, John S

Biochem Biophys Res Commun 71(4):952958 Maiorino M, Bosello V, Cozza G, Roveri A, Toppo S, Ursini F