glp 1 receptor brain GLP-1 agonists show promise in treating substance use disorders JCI - Glucagon-like peptide-1 receptors

Hyperglycemia and insulin resistance: Some bodybuilders report that retatrutide is harder to manage at very high carbohydrate intakes

Patients who switched from tirzepatide to orforglipron maintained a mean 74.7% of their body weight reduction from the SURMOUNT-5 trial compared with those in the placebo group, which maintained a mean 49.2% of their weight loss

If your blood pressure consistently improves, your provider can decide whether your medication plan should stay the same or be adjusted

This segment aired on March 24, 2026.

Low electrolytes can also contribute to symptoms like: Fatigue Dizziness Headaches Muscle weakness Trouble exercising and recovering Electrolyte supplements, such as low-sugar electrolyte drink mixes, can keep your energy up and help with muscle and nerve functions, along with digestion, while weight loss is occurring

Tracking your progress and adjusting your approach Managing GLP-1 constipation is not a one-size-fits-all proposition