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If additional glycemic control is needed, increase to 9 mg once daily

Similarly, the Cardiac and Metabolic Effects of Semaglutide in Heart Failure With Preserved Ejection Fraction study focuses on obese patients with HFpEF to evaluate improvements in cardiac structure, exercise tolerance, and metabolic health [64]

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Maintaining Optimal Cellular Responsiveness Beyond receptor desensitization, continuous administration of any bioactive compound might lead to other adaptive changes within the physiological system being studied

Ciardullo and Perseghin, 2022)