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Receptor Targeting Amylin vs Dual GLP-1/Glucagon Agonism Cagrilintide binds to amylin receptors located primarily in the area postrema

Nature 616 , 764773 (2023)

Demirel, R

However, the study was small, lacked a placebo control and evaluated biomarkers rather than long-term clinical outcomes

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The study excluded cross-over trials without washout period, those in critically ill patients, pregnant or breast-feeding women, multicomponent interventions and active control groups with tea or coffee