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Characterizing the mechanism of action for mRNA therapeutics for the treatment of propionic acidemia, methylmalonic acidemia, and phenylketonuria

Besides the activation loop (A-loop), the second most common site for amino acid substitutions is the GSGSFG phosphate-binding loop (P-loop) at residues 464-469 (94)

Exenatide formulations show variable nausea rates: the twice-daily immediate-release preparation (Byetta) tends to produce higher rates of nausea (approximately 3050%), whilst the once-weekly extended-release formulation (Bydureon) demonstrates improved tolerability with nausea rates of approximately 1424%, according to their respective SmPCs