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Peptides operate through specific cellular signaling pathways
However, clinical trials have identified a potential link between rapid glycaemic improvement with semaglutide and temporary worsening of pre-existing diabetic retinopathy
The GLP-1 binding on the GLP-1Rs starts several signalizing pathways in the neurons, reducing inflammation, oxidative stress, apoptosis, and a-synuclein deposition
However, most candidates require standardization across labs, ethnic groups, and disease stages before clinical deployment
You could say that the field has become the victim of its own success
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