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According to Mayo Clinic, creatine is a compound that comes from three amino acids, AKA the building blocks of protein

ACBP-3, alone or in conjunction with cisplatin, inhibits xenograft tumor development in vivo , and enhances chemotherapy tolerance in a mouse model by decreasing toxicity during tests (28)

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Miller M, Cannon C, Murphy S, Qin J, Ray K, Braunwald E

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As a result, Sox9 was activated and testes developed, leading to complete internal and external male development, they reported in Nature Communications