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The ultimate classification of GLP-1 agonists as game-changing or overhyped will depend on societys ability to address the implementation challenges that currently limit their transformative potential

1Model based estimates based on an analysis of covariance model including treatment and type 2 diabetes status as factors and baseline value as a covariate 2Not included in the pre-specified hierarchical testing 3Model based estimates based on a mixed model for repeated measures including treatment and type 2 diabetes status as factors and baseline values as a covariate 4Baseline value is the geometric mean Overview of Clinical Trial in Pediatric Patients WEGOVY was evaluated in a 68-week, double-blind, randomized, parallel group, placebo-controlled, multi-center trial in 201 pubertal pediatric patients aged 12 years and older with BMI corresponding to 95th percentile standardized for age and sex (Study 7) (NCT#04102189)

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The company also argues that Rejuva could be easier to tolerate, since the therapy would really only stimulate added production in response to food, as opposed to the high circulating levels of GLP-1 induced by drugs

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