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Phase 2 trial data (Jastreboff et al., NEJM 2023) demonstrated average weight reductions of approximately 1724% over 48 weeks notably higher than currently approved GLP-1 receptor agonists such as semaglutide, though direct comparisons are limited by differences in trial populations and designs

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Warning signs include dark urine, dizziness , a dry mouth, reduced urination, and feeling unusually weak

As federal policies plan to widen access and lower the cost of these anti-obesity drugs through Medicare and Medicaid, their user base could increase by 7 million

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