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Practice Point 4.3.3: GLP-1 RA should not be used in combination with DPP-4 inhibitors

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In the mid-2000s, Novo Nordisk had developed a peptide called liraglutide that mimics the gut hormone glucagon-like peptide-1 (GLP-1), leading to antidiabetic effects and weight loss

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For patients taking GLP-1 agonists, the mechanism that helps regulate appetite and glucose control can also slow gastric emptying, contributing to constipation

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