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Appl Environ Biotechnol 3:4

The published research literature describes Epithalon as exerting effects through several proposed mechanisms: induction of telomerase reverse transcriptase (hTERT) gene expression and corresponding telomerase enzymatic activity

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The linkage of NAD + metabolism to the internal clocks is firstly evidenced by that the NAD(P) + /NAD(P)H ratio modulates the DNA-binding activity of the core oscillators, such as CLOCK: BMAL1 and NPAS2: BMAL1 heterodimers