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Although, in general, patients who are heterozygous for SLC22A5 mutations have been thought to be asymptomatic, Garavaglia et al

Until now, research on immune cells primarily focused on FAO, rather than the potential role of FA metabolites in immune cell functioning, such as acylcarnitines

, The increased hydrophobicity of fatty monoacids compared to fatty diacids affects the solubility, receptor pharmacology, and biophysical properties of the derivatized molecule

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These data are consistent with alanine substitution of TMD residues lining the binding cavity generally having limited impact on exendin-P5 affinity, suggesting its affinity is largely driven by interactions with the ECD (Figures 4-5, Supplemental Figure 9)

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