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Scenesse (afamelanotide acetate, Clinuvel Pharmaceuticals) is an FDA-approved subcutaneous implant for the reduction of phototoxicity in adult patients with erythropoietic protoporphyria
In the STEP-1 trial published in The New England Journal of Medicine in 2021, once-weekly subcutaneous semaglutide at 2.4 mg produced a mean placebo-adjusted body weight reduction of 12.4% at 68 weeks in adults with overweight or obesity (Wilding et al., NEJM, 2021)
Even a consistent daily deficit of 500 kcal would theoretically produce around 0.5 kg of fat loss per week a change that may be imperceptible on the scales when overlaid with day-to-day weight variation
meanwhile, another RCT observed a reduction of epicardial adipose tissue (EAT) thickness and its glucose uptake in T2D patients with SGLT-2i treatment [24, 25]
Conditions Addressed Tanya Zboril, NP of TBT Medicals goal is to strengthen the overall health and wellness of Kitchener-Waterloo patients with personalized integrative care