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During this initial stage, there is an increase in the permeability of the glomerular capillaries, which leads to loss of protein in the urine, especially albumin, commonly known as proteinuria or albuminuria with a corresponding parallel decrease in estimated glomerular filtration rate (eGFR) below 60 mL/min/1.73 m 2 [19]

Despite the contradictory data regarding kidney outcomes, two surrogate outcomes benefit the most from combined therapy: the decline in eGFR slope and the reduction in urinary albumin-to-creatinine ratio

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10.1016/j.stem.2016.05.023 169 SchlegelmilchK.MohseniM.KirakO.PruszakJ.RodriguezJ

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