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Treatment with tirzepatide notably ameliorated these histopathological changes, as evidenced by a reduction in both fat vacuoles and inflammatory infiltration (Fig
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Since TNF-alpha is a major cytokine produced by tissue-resident macrophages and circulating TNF-alpha is associated with obesity in T2DM [204], blocking TNF-alpha seems a plausible therapeutic strategy
On the other hand, semaglutide is already well-known and available under brand names like Ozempic and Wegovy
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