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LUIGI FONTANA: Calorie restriction with optimal nutrition can prevent multiple chronic disease, cancer, diabetes, cardiovascular disease, less neurodegeneration, less sarcopenia, less frailty

This significant cytoplasmic accumulation of HIF-1 appears to be a result of enhanced protein stabilization before its translocation to the nucleus

Interestingly, the baseline escape latency in older control animals was significantly higher than in young controls, confirming the age-related decline in spatial memory that we'd expect to see

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Different analyzers used in high resolution MS, including time of flight (TOF), and Orbitrap enable the determination of the elemental composition (assignment of the most probable sum formula) of a compound by measuring the exact mass and comparing the isotopic profile of the obtained spectrum with the theoretical profile