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DMF, via the covalent modification of KEAP1 cysteine residues, leads to reliable NRF2 stabilization, with dose-dependent effects that are cytoprotective at low doses

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One should consider the primary phase lesion and hemorrhaging that results from mechanical damage during SCI as well as the secondary phase lesion that lasts several hours or even several months and is accompanied by edema, hemorrhage, inflammation, and cytotoxic edema [44,45,46,47] and may extend to the white matter area and lead to white matter degeneration and damage [48, 49]

1997, 272: L148-L154

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