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The medication remains active, but increased intake has offset its effects

The median follow-up duration was 1 year (IQR: 0.52 years), with key findings including a median weight loss of 11.7 kg and a median BMI at the most recent follow-up of 31.2 kg/m 2 , reflecting a median reduction of 3.7 kg/m 2

The ones who made it to week 48

However, some individuals report early sensations such as mild nausea or reduced appetite within the first few hours following the injection

The single-molecule approach (tirzepatide, retatrutide) offers advantages in simplicity and potentially in pharmacokinetics