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It is still phase 2 data in fewer than 100 people, and MASLD is not an approved indication for retatrutide, but it is the result driving much of the scientific interest in the molecule

The difference between Melanotan 1 and Melanotan 2 isn't just a minor variation

For example, people with a history of heavy drinking who took semaglutide (the active ingredient in Ozempic and Wegovy) reported fewer alcohol cravings, drank less when they did drink and had fewer heavy drinking episodes than those who took a placebo, according to a 2025 double-blind, randomized clinical trial published in JAMA Psychiatry

Bone metastases

We don't see that with the drugs," she says

They are contraindicated in patients with a personal or family history of medullary thyroid cancer or multiple endocrine neoplasia syndrome type 2