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Physicians considering this intervention for patients with cardiac risk factors must consider the long term impact of increased nutritional fat content and low fiber diet, such as cardiovascular damage and renal complications like kidney stones [103]

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doi: 10.1177/1352458514568173 240 von MoltkeJ.JiM.LiangH

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Pro-inflammatory adipokines (e.g., leptin, resistin) and adipose-derived exosomes (carrying miRNAs like miR-3074-5p) create a chronic inflammatory joint microenvironment by polarizing synovial macrophages toward an M1 phenotype and inhibiting anti-inflammatory adiponectin (1618)