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Bone age remained always comparable with chronological age

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The same group reported the synthesis of the Aib-enkephalin pentapeptide (H-Tyr-Aib-Aib-Phe-Leu-NH 2 ) (Figure 20) using greener solvents such as 2-methyltetrahydrofuran (2-MeTHF), which can be derived from renewable resources [117], and cyclopentyl methyl ether (CPME) as environmentally friendlier alternatives to DMF [118]