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While inhibition of COX-1 can have serious gastrointestinal consequences, selective inhibition of COX-2 carries cardiovascular risks

Accordingly, substituting the C-terminal L585 residue of albumin with an amino acid resistant to the enzymatic cleavage by CPA proved challenging without compromising receptor engagement

doi: 10.3906/biy-2005-102 2 AliN

Use an insulin syringe (typically 0.5 mL or 1 mL capacity with a 29-31 gauge needle)

Its approved status is reflected in the ChEMBL registry at maximum phase 4

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